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Additionally, during illness or infection , the body produces more free radicals

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Without sufficient glutathione, melanin regulation gets disrupted, leading to hyperpigmentation or uneven spots

10.3390/biom11101478 2 AumannK

Finally, it discusses emerging frontiers, including the potential of COFs to induce TLS formation, mediate novel forms of programmed cell death (such as pyroptosis, ferroptosis, and PANoptosis), and integrate diagnostics with therapy in a single platform (Section 9)